Notes for sections (a) thought (k)

1 Herkenham, M., Lynn, A.B., et al., (1990) "Cannabinoid Receptor Localization in Brain," Proceedings of the National Academy of Sciences, 87:1932-1936, 1990.

2 Paton, W.D.M., (1976) Concluding Summary. In Nahas, G., Paton, W.D.M., Idanpaan-Heikkila, J. (eds.), Marihuana: Chemistry, Biochemistry, and Cellular Effects. New York: Springer-Verlag, 1976. (Proceedings of the Satellite Symposium on Marihuana of the 6th International Congress of Pharmacology held July 26-27, 1975 in Helinski, Finland.) pg. 552.

3 Paton, W.D.M. (1979) Concluding Summary. In Nahas, G., Paton, W.D.M., Braude, M.C. (eds.), Marihuana: Biological Effects: Analysis, Metabolism, Cellular Responses, Reproduction, and Brain: Proceedings of the Satellite Symposium on Marihuana, 7th International Congress Of Pharmacology. New York: Pergamon Press, 1979. (International Congress of Pharmacology, 7th, 1978, Paris. Also known as Rheims Conference.) pg. 736.

4 Harvey, D.J., Paton, W.D.M., Marihuana '84, Final Summary. In Harvey, et al, (1985). pg. 734.

5 Nahas, (1984). pg. 111-112.

6 Paton, (1976). pg. 552.

7 Herkenham, M. (1992), "Cannabinoid Receptor Localization in Brain: Relationship to Motor and Reward Systems," P.W. Kalivas and H.H. Samson (eds.), The Neurobiology of Drug and Alcohol Addiction, Annals of the American Academy of Sciences. 654:19-32, 1992. pg. 19.

8 Pertwee, R.G. (1988) "The Central Neuropharmacology of Psychotropic Cannabinoids." Pharmac. Ther. 36:189-261.

9 Martin, B.R. (1986) "Cellular Effects of Cannabinoids." Pharmacological Reviews 38:45-74. pg. 46.

10 Herkenham (1992) pg. 19.

11 ibid., pg. 420.

12 51 FR 22947

13 Devane, W.A., Dysarz, F.A., et al (1988)

14 Herkenham, M., Lynn, A.B., et al., (1990) "Cannabinoid Receptor Localization in Brain," Proceedings of the National Academy of Sciences, 87:1932-1936, 1990.

15 ibid., pg. 1932.

16 Martin (1986)

17 Thomas, B., Compton, D., Martin, N. (1990) Characterization of the Lipophilicity of Natural and Synthetic Analogs of D9-Tetrahydrocannabinol and Its Relationships to Pharmacological Potency. Journal of Pharmacology and Experimental Therapeutics . 255:2 pg. 624 - 630.

18 ibid. pg. 629-630.

19 Herkenham et al (1990)

20 Matsuda, L., Lolait, S., et al (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564.

21 Lichtman, A.H., Martin, B.R. (1991) Spinal and Supraspinal Components of Cannabinoid-Induced Antinociception. Journal of Pharmacology and Experimental Therapeutics. 258:517-523.

22 Prescott, W.R., Gold, L.H., Martin, B.R. (1992) Evidence for separate neuronal mechanisms for the discriminative stimulus and catalepsy induced by D9-THC in the rat. Psychopharmacology (1992) 107:117-124.

23 Richardson, S., Mirasedeghi, S., Lynn, A., Johnson, <.R., Melvin, L.S., Herkenham, M., and Rice, K. Synthetic and Biological Studies of Potential Affinity Ligands for the Cannabinoid Receptor Based on CP-55,244. In: Problems of Drug Dependence, 1990. Proceedings of the 52th Annual Scientific Meeting, The Committee on Problems of Drug Dependence, Inc. Harris, L. (ed.), National Institute on Drug Abuse Research Monograph 105. Washington, D.C.: U.S. Govt. Print. Off., 1990. pg. 140 - 146. pg. 140.

24 Thomas, B., Wie, X., Martin, B. (1992) Characterization and Autoradiographic Localization of the Cannabinoid Binding Site in Rat Brain Using [3H]11-OH-D9-THC-DMH. Journal of Pharmacology and Experimental Therapeutics . 263:3 pg. 1383 - 1390.

25 Pertwee, R. (1993) The Evidence for the Existence of Cannabinoid Receptors. General Pharmacology. 29:4 pg. 811-824. pg. 821.

26 ibid. pg. 821.

27 Pratt, J.A. (1991) "Psychotropic Drug Tolerance and Dependence: Common Underlying Mechanisms?" In Pratt, J.A. (ed.) The Biological Bases of Drug Tolerance and Dependence. London: Academic Press. 1991., pg. 4-5.

28 Nahas (1973)

29 Nahas and Frick (1981)

30 Nahas (1990) pg. 261.

31 Abood and Martin (1992) pg. 204.

32 Hollister, L.E.(1986), "Health Aspects of Cannabis", Pharmacological Reviews, 38:1, 1-20.

33 Pratt, J.A. (1991) .

34 ibid., pg. 8.

35 Nahas (1984) pg. 203.

36 Oviedo, A., Glowa, J, and Herkenham, M. (1993), "Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study." Brain Research, 616:293-302.

37 ibid., pg. 293.

38 Koob, G.B. and Bloom, F.E. (1988), "Cellular and molecular mechanisms of drug dependence." Science, 242:715-723. cited in Oviedo, et al (1993) and in Pratt (1992).

39 Oviedo, et al. (1993) pg. 300.

40 ibid., pg. 300.

41 Hollister, L. (1986) pg. 7-8.

42 Abood and Martin (1992) pg. 202.

43 Compton, D.R., Rice, K.C., et al Cannabinoid Structure-Activity Relationships: Correlation of Receptor Binding and in Vivo Activities. (1993) Journal of Pharmacology and Experimental Therapeutics. 265:218-226. 1993.

44 ibid. pg. 222.

45 ibid. pg. 225

46 Melvin, L.S., Milne, G.M., et al. (1993) Structure-Activity Relationships for Cannabinoid Receptor-Binding and Analgesic Activity: Studies of Bicyclic Cannabinoid Analogs. Molecular Pharmacology. 44: 1008-1015. 1993.

47 Smith, P.B., Welch, S.P., Martin, B.R. (1994) Interactions between D9-Tetrahydrocannabinol and Kappa Opiods in Mice. Journal of Pharmacology and Experimental Therapeutics. 268:1381-1387. 1994.

48 Rodriguez De Foncesa, F., Gorriti, M., et al (1994) Downregulation of Rat Brain Cannabinoid Binding Sites After Chronic D9-Tetrahydrocannabinol Treatment. Pharmacology, Biochemistry, and Behavior. 47:33-40.

49 Lynn, A.B., and Herkenham, M. (1993) "Localization of Cannabinoid Receptors and Nonsaturable High-Density Cannabinoid Binding Sites in Peripheral Tissues of the Rat: Implications for Receptor-Mediated Immune Modulation by Cannabinoids" Journal of Pharmacology and Experimental Therapeutics, 268:3 1612-1623.

50 ibid., pg. 1622.

51 Abood and Martin (1992).

52 Nahas, G. (1976) Keep Off The Grass: A Scientist's Documented Account of Marijuana's Destructive Effects. New York: Readers Digest Press, 1976. pg. 116-122.

53 Nahas, G.G., Sucia-Foca, N., et al. (1974), "Inhibition of cellular mediated immunity in marijuana smokers." Science (Washington, D.C.) 183:419-420. cited in Lynn and Herkenham (1993) .

54 Hollister, L. Marijuana and Immunity. Journal of Psychoactive Drugs. Vol. 20(1):3-8, 1988.

55 Lynn and Herkenham (1993). pg. 1620.

56 ibid., pg. 1621.

57 ibid., pg. 1621.

58 ibid., pg. 1621.

59 Wert, R.C., Raulin, M.L., "The Chronic Cerebral Effects of cannabis Use. I. Methodological Issues and Neurological Findings." International Journal of the Addictions, 21(6), 605-628, 1986.

60 Wert, R.C., Raulin, M.L., "The Chronic Cerebral Effects of cannabis Use. II. Psychological Findings and Conclusions." International Journal of the Addictions, 21(6), 629-642, 1986.

61 U.S. Department of Health and Human Services, (1991) Drug Abuse and Drug Abuse Research, the Third Triennial Report to Congress From the Secretary, Department of Health and Human Services. Washington D.C.: Government Printing Office. 1991. (DHHS Publication No. (ADM)91-1704.) pg. 138 - 140.

62 Howlett, et all (1990) pg. 423.

63 Johnson, M.R., Rice, K.C., Howlett, A., Melvin, L.S., and Herkenham, M. The Cannabinoid Receptor-Pharmacologic Identification, Anatomical Localization and Cloning. In: Problems of Drug Dependence, 1991. Proceedings of the 53th Annual Scientific Meeting, The Committee on Problems of Drug Dependence, Inc. Harris, L. (ed.), National Institute on Drug Abuse Research Monograph 119. Washington, D.C.: U.S. Govt. Print. Off., 1992. pg. 86-90. pg. 90.

64 Devane, W.A., Hanus, L, et al (1992) "Isolation and structure of a brain constituent that binds to the cannabinoid receptor." Science, 1992; 258:1946-1949.

65 Martin, 1995 pg. 1761.

66 Rinaldi-Carmona, M., Barth, F., et al (1994). "SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Letters 350 (1994) pg. 240 - 244.

67 Di Marzo, V., Fontana, A., et al. (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature. 372:686-691. 1994.

68 Childers, S.R., Sexton, T., Roy, M.B. (1994) Effects of Anandamide on Cannabinoid Receptors in Rat Brain Membranes. Biochemical Pharmacology. 47:711-715, 1994.

69 Smith, P.B., Compton, D.R., et al. The Pharmacological Activity of Anandamide, a Putative Endogenous Cannabinoid, in Mice. Journal of Pharmacology and Experimental Therapeutics. 270:219-227. 1994.

70 Fride, E., Barg, J., et al (1995) Low Doses of Anandamides Inhibit Pharmacological Effects of D9-Tetrahydrocannabinol. Journal of Pharmacology and Experimental Therapeutics. 272:699-707, 1995.

71 Mechoulam, R. (1986), "Interview with Professor Raphael Mechoulam, Codiscoverer of THC", The International Journal of the Addictions, 21(4&5), 579-587, 1986. (The interview was conducted by Stanley Einstein in Jerusalem on January 14, 1985.) pg. 587.

72 R. Mechoulam, W.A. Devane, A. Breuer and J. Zahalka, (1991) "A Random Walk Through A Cannabis Field", Pharmacology, Biochemistry, & Behavior, Vol. 40, pp. 461-464.

73 54 Fed. Reg. 53,779 (1989)

74 57 Fed. Reg. 10,499 (1992)

75 57 Fed. Reg. 10,499 (1992)

76 54 Fed. Reg. 53,774 (1989)

77 54 Fed. Reg. 53,781 (1989)

78 54 Fed. Reg. 53,782 (1989)

79 54 Fed. Reg. 53,782 (1989)

80 54 Fed. Reg. 53,768 (1989)