The significance of this neurobiological research on reinforcement
mechanisms in the brain will be discussed in section 7 of
New scientific knowledge on the mechanism of action of
marijuana in the human brain will be discussed in section
3 of this petition, after a review of pharmacological knowledge
in section 2.
Scientific and medical evidence contrasting marijuana's
mechanism of action in the brain with that of drugs of abuse
such as heroin, cocaine, and amphetamine provide additional
validity to the assertion that the non self-administration
of marijuana or THC by animals is an indication that the drug
does not have a significant dependence liability. This will
be discussed in more detail in section 7. The relationship
between marijuana and other cannabinoids will be addressed
briefly in section 2 and more completely in section 8.
Sections 4, 5, and 6 of the petition will review data
and reports which provide evidence of marijuana's actual use
in society and its actual ramifications; this evidence will
provide additional validity to the assertion that animal models
are accurate in predicting marijuana's abuse potential.